HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
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چکیده
منابع مشابه
HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
Protein disulfide isomerase (PDI) present at platelet surfaces has been considered to play an important role in the conformational change and activation of the integrin glycoprotein IIb/IIIa (GPIIb/IIIa) and thus enhances platelet aggregation. Growing evidences indicated that platelet surface PDI may serve as a potential target for developing of a new class of antithrombotic agents. In the pres...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2017
ISSN: 2213-2317
DOI: 10.1016/j.redox.2017.05.019